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Season 2, Episode 12: "Grandma Got Run Over by a Reindeer"

In this episode, Burke tries to get into the Christmas spirit, only to find out much to his chagrin that Cristina is Jewish. At work, things tense up when Cristina sides with a young patient whose mother attempts to convince him that Santa is giving him a heart this year. Cristina is her usual self, blunt and irate, which is why Burke is turned off by her total Grinch attitude. But we see Cristina open up about the personal reason why she decided to go into medicine and talk candidly to the young boy who doesn't want a new heart.

Image Source: ABC via Giphy