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Season 3, Episode 25: "Didn't We Almost Have It All?"

This gut-punching episode follows Cristina on her wedding day, during which she entirely changes herself to please Burke's family. In short of spoiling the plot, let's just say that things don't end well and that you'll probably be sobbing every time you listen to Ingrid Michaelson's "Keep Breathing." Still, we're glad to see Cristina come back to her senses after everything goes down in the season three finale.

Image Source: ABC via Giphy