End products of the COX enzyme are involved in coagulation and hemostasis, meaning they play a key role in platelet aggregation in response to injury and trauma, explains Dr. Linder. This helps with blood clot formation and the control of bleeding.
But “with long-term use or overuse of ibuprofen, patients may be more at risk for increased or uncontrolled bleeding,” he explains. Additionally, you may experience high blood pressure when you take ibuprofen in excess, putting unnecessary strain on your heart.