By the start of the 1980s, boxing legend Muhammad Ali remained determined to hold onto his title of being the greatest of all time. In an attempt to continue his legacy and make money, Ali, who then was struggling with early symptoms of Parkinson's disease, arranged to box life-long friend and boxing opponent Larry Holmes. The fight was mostly one-sided, as Ali struggled to both attack and defend himself, and ultimately resulted in a loss as well as Ali's retirement.