The Big Easy's world-famous Mardi Gras celebration culminates on March 5 this year (Fat Tuesday), but there is a glassful of other reasons to head down south after the parades subside (like the best Cajun food you've ever tasted and walking the stunning French Quarter). Plus, if a party is what you're after, Bourbon Street doesn't stop just because Mardi Gras ends.
Also, as Brown pointed out, NOLA isn't an adult-only holiday; it's a great place to bring the kids along, too. "There's great food (who doesn't like a beignet?), enchanting streets, and so much weird and wild history that both kids and adults will revel in."