Packaged in an air-tight tube, the Shiseido Vital Perfection Intensive Wrinkle Spot Treatment (£90) contains retinol and the brand's proprietary ReNeura Technology++ (which it claims helps jump-start skin cells into action to ward off the signs of ageing). The cream can be applied like an eye cream (under and along the sides of the eyes), around the mouth and sides of the nose, over the neck, or anywhere you have deep wrinkles, dark spots, or sagging that you want to treat.